Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation
Identifieur interne : 003177 ( Main/Exploration ); précédent : 003176; suivant : 003178Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation
Auteurs : Ioannis U. Isaias [Italie] ; Riccardo Benti [Italie] ; Stefano Goldwurm [Italie] ; Michela Zini [Italie] ; Roberto Cilia [Italie] ; Paolo Gerundini [Italie] ; Alessio Di Fonzo [Pays-Bas, Italie] ; Vincenzo Bonifati [Pays-Bas, Italie] ; Gianni Pezzoli [Italie] ; Angelo Antonini [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-08.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Amino Acid Substitution, Corpus Striatum (metabolism), Dopamine, Dopamine Plasma Membrane Transport Proteins (metabolism), Gly2019Ser mutation, Humans, Ioflupane(123I), LRRK2, Mutation, Nervous system diseases, PARK8, Parkinson Disease (genetics), Parkinson Disease (metabolism), Parkinson disease, Photon, Polymorphism, Single Nucleotide, Protein-Serine-Threonine Kinases (genetics), Single photon emission tomography, [123I]ioflupane SPECT.
- MESH :
- chemical , genetics : Protein-Serine-Threonine Kinases.
- chemical , metabolism : Dopamine Plasma Membrane Transport Proteins.
- genetics : Parkinson Disease.
- metabolism : Corpus Striatum, Parkinson Disease.
- Amino Acid Substitution, Humans, Mutation, Polymorphism, Single Nucleotide.
Abstract
We measured striatal dopamine transporter binding using [123I]ioflupane and SPECT in patients with Parkinson's disease associated with the LRRK2 (PARK8) Gly2019Ser gene mutation (LRRK2‐PD) and in gene‐negative patients with idiopathic Parkinson's disease (IPD) of comparable disease duration and severity. The LRRK2‐PD group consisted of a total of 10 patients (3 sporadic) with mean age 62 ± 14 years, disease duration 9 ± 3 years, and UPDRS III motor score 21.60 ± 6.65. The control IPD group consisted of 15 patients with mean age 59 ± 9 years, disease duration 9 ± 5 years, and UPDRS III motor score 23.80 ± 8.69. [123I]ioflupane–specific uptake ratios were calculated for caudate nucleus and putamen using the occipital cortex as reference region. We found no differences between the LRRK2‐PD group and IPD in all items studied. In particular, putamen and caudate uptake values as well as side asymmetry indexes and putamen/caudate ratios all revealed comparable between‐group values. We conclude that in these patients carrying the LRRK2 Gly2019Ser mutation, the neurodegenerative process results in a pattern of nigrostriatal dopaminergic dysfunction similar to that observed in IPD. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.20909
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Substitution</term>
<term>Corpus Striatum (metabolism)</term>
<term>Dopamine</term>
<term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term>
<term>Gly2019Ser mutation</term>
<term>Humans</term>
<term>Ioflupane(123I)</term>
<term>LRRK2</term>
<term>Mutation</term>
<term>Nervous system diseases</term>
<term>PARK8</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson disease</term>
<term>Photon</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Single photon emission tomography</term>
<term>[123I]ioflupane SPECT</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Substitution</term>
<term>Humans</term>
<term>Mutation</term>
<term>Polymorphism, Single Nucleotide</term>
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<term>Ioflupane(123I)</term>
<term>Mutation</term>
<term>Parkinson maladie</term>
<term>Photon</term>
<term>Système nerveux pathologie</term>
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<front><div type="abstract" xml:lang="en">We measured striatal dopamine transporter binding using [123I]ioflupane and SPECT in patients with Parkinson's disease associated with the LRRK2 (PARK8) Gly2019Ser gene mutation (LRRK2‐PD) and in gene‐negative patients with idiopathic Parkinson's disease (IPD) of comparable disease duration and severity. The LRRK2‐PD group consisted of a total of 10 patients (3 sporadic) with mean age 62 ± 14 years, disease duration 9 ± 3 years, and UPDRS III motor score 21.60 ± 6.65. The control IPD group consisted of 15 patients with mean age 59 ± 9 years, disease duration 9 ± 5 years, and UPDRS III motor score 23.80 ± 8.69. [123I]ioflupane–specific uptake ratios were calculated for caudate nucleus and putamen using the occipital cortex as reference region. We found no differences between the LRRK2‐PD group and IPD in all items studied. In particular, putamen and caudate uptake values as well as side asymmetry indexes and putamen/caudate ratios all revealed comparable between‐group values. We conclude that in these patients carrying the LRRK2 Gly2019Ser mutation, the neurodegenerative process results in a pattern of nigrostriatal dopaminergic dysfunction similar to that observed in IPD. © 2006 Movement Disorder Society</div>
</front>
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